VariantPulseCached evidenceADr. A. Kassim, open settings
VariantPulseThe interpretation moved across the clinically actionable boundary since this result was reported.
2023 · On file
Uncertain significance
Reported 20 Mar 2023
Today · ClinVar
Likely pathogenic
ClinVar last evaluated 31 Jul 2025 · Single submitter
The changed variant and every historical record that carries it. Select a record to see its detail.
Changed variant
MYBPC3
c.776delinsTT
VUSLikely pathogenic
VP-10775
Not reviewed35-44 · Cardiology
Since the 2023 report, the consensus for MYBPC3 c.776delinsTT has moved from uncertain significance to likely pathogenic. That reading rests on a single submission at limited review confidence, single submitter. That crosses the clinically actionable boundary, so management guidance issued on the original interpretation may no longer be the right guidance. 2 records on file carry this variant and have not yet been reassessed.
Composed from the structured fields of the records cited on this page. Requires clinical verification before it informs any decision.
Each source is shown as it reports itself. VariantPulse does not merge them into a single verdict.
| Source | Classification | Review level | Last updated | Strength | |
|---|---|---|---|---|---|
| ClinVar1 submission on record. | Likely pathogenic | Single submitter | 31 Jul 2025 | Limited1 of 4 review criteria met | VCV004689837 |
| Population frequencyHighest reported allele frequency carried on the source record. | Not reported | No frequency data | 31 Jul 2025 | Reference observation | |
| LiteraturePublications linked to this variant record. | 0 indexed publications | PubMed index | No linked publications | Supporting context | |
| Regional Evidence IndexModelled regional aggregation maintained inside this workspace | Likely pathogenic | 0 regional observations | 25 Sept 2026 | Cohort 3,042 | |
| This institutionThe interpretation issued to the patient at the time of testing. | Uncertain significance | Internal report | 20 Mar 2023 | On record |
Global · ClinVar
Likely pathogeniccriteria provided, single submitter · Last evaluated 31 Jul 2025
Regional · Regional Evidence Index
Likely pathogenic0 observations in 3,042 · updated 25 Sept 2026
Sources consistent
Both lanes fall in the same clinical band.
Global
Read from ClinVar, which aggregates submissions dominated by European-ancestry cohorts.
Regional
Modelled regional aggregation maintained inside this workspace.
VariantPulse analysis
Both sources place this variant in the same band, so there is no divergence to resolve. CTGA lists this frameshift in a UAE patient as likely pathogenic for left ventricular non-compaction (record dated 2020). It did not appear in ClinVar until after January 2023 (first classified likely pathogenic, July 2025, single submitter). Another case where a regional catalogue carried the answer before global databases did.
MYBPC3 c.776delinsTT. The DNA is unchanged. The evidence around it is not.
A triage signal for the queue. Not a clinical risk score, and not a statement about any individual.
The same records as a list, for scanning and screen readers.