VariantPulseEvidence monitor liveADr. A. Kassim, open settings
VariantPulseAbout this workspace
How VariantPulse is put together, what it is allowed to do, and what it deliberately does not do.
Evidence flows in one direction. The record system is only ever read.
Record system
Historical genomic findings, read-only.
Variant normaliser
HGVS resolved to stable identifiers and a single internal key.
Evidence sources
ClinVar, regional index, literature index.
Diff engine
Deterministic band comparison. No model involved.
Impact mapper
Finds every record carrying a changed variant.
Evidence intelligence
Composes the brief from the cited records.
Review queue
Prioritised cases with full reasoning attached.
Human decision
A clinician decides. Nothing is written automatically.
Change detection never depends on a language model. Classifications are normalised onto a fixed taxonomy and compared by band, so the same inputs always produce the same verdict. A model is only used to phrase the summary, and only from evidence that is already on screen.
Four responsibilities, each one inspectable from the case it produced.
Evidence
Reads current classifications and summarises what the sources state.
Conflict
Detects disagreement between global consensus and regional evidence.
Impact
Maps a changed variant back onto the historical records that carry it.
Briefing
Assembles a clinician-ready brief with its citations attached.
This workspace is not a certified medical device and has not been through regulatory assessment. It is decision support for a clinical team, not a diagnostic system.
Reclassification is not an edge case. It is the normal behaviour of a field where evidence accumulates faster than reports are revisited. A programme sequencing at population scale accumulates that debt continuously, and the gap widens quietly. Watching it is a systems problem, and it is the problem VariantPulse is built to solve.