CriticalClassification driftVP-R-2026-001Raised
BRCA1c.5056C>T (p.His1686Tyr)BRCA1 interpretation crossed the actionable boundary
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighRegional conflictVP-R-2026-002Raised
HBBc.380T>G (p.Val127Gly)HBB regional and global evidence disagree
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighClassification driftVP-R-2026-003Raised
BRCA2c.7847C>T (p.Ser2616Phe)BRCA2 interpretation crossed the actionable boundary
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighClassification driftVP-R-2026-004Raised
TP53c.589G>A (p.Val197Met)TP53 interpretation crossed the actionable boundary
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighClassification driftVP-R-2026-005Raised
LDLRc.1381G>T (p.Gly461Cys)LDLR interpretation crossed the actionable boundary
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighClassification driftVP-R-2026-006Raised
PTENc.149T>C (p.Ile50Thr)PTEN interpretation crossed the actionable boundary
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighClassification driftVP-R-2026-007Raised
HBBc.364G>C (p.Glu122Gln)HBB interpretation crossed the actionable boundary
Open case- Evidence confidence
- Moderate2 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighClassification driftVP-R-2026-008Raised
MYBPC3c.26-2A>GMYBPC3 interpretation crossed the actionable boundary
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
HighClassification driftVP-R-2026-009Raised
MYBPC3c.776delinsTT (p.Ala259fs)MYBPC3 interpretation crossed the actionable boundary
Open case- Evidence confidence
- Limited1 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
MediumRegional conflictVP-R-2026-010Raised
CFTRc.601G>A (p.Val201Met)CFTR regional and global evidence disagree
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
MediumConsensus conflictVP-R-2026-011Raised
BRCA1c.5123C>T (p.Ala1708Val)BRCA1 submitters no longer agree
Open case- Evidence confidence
- Limited1 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
LowEvidence weakenedVP-R-2026-012Raised
BRCA2c.9538C>T (p.Leu3180Phe)BRCA2 evidence now favours a benign reading
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
LowEvidence weakenedVP-R-2026-013Raised
TP53c.784G>A (p.Gly262Ser)TP53 evidence now favours a benign reading
Open case- Evidence confidence
- Strong3 of 4 review criteria met
- Assigned
- Unassigned
- Status
- Needs review
VariantPulse